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Consequently, the newly revealed combined NO-system background (i.e., common therapy effect, common NO-response) [59,70] might, for BPC 157 therapy, particularly allocate matching “positive-like” and “negative-like” symptoms or indicate specific circuits between the involved brain areas, mesolimbic pathways in the “positive-like” symptoms and fronto-cortical temporal and cortico-striatal pathways in the “negative-like symptoms” [1]