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Symptoms of Compromised Immunity: Frequent illnesses, slow recovery from illness, and persistent infections

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By upregulating the expression of multiple viral gene products, especially E6 and E7 oncoproteins, these high-risk HPV types, can inhibit p53 and RB tumour suppressors, respectively, which can lead to the disruption of critical cellular regulatory pathways controlling cell cycle entry, differentiation, apoptosis, cell polarity 6 , and to the establishment of an aberrant cellular metabolism 5