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The benzyl alcohol preservative has been linked to severe toxicity in this population, including a potentially fatal condition known as “gasping syndrome.” Newborns have immature metabolic pathways and cannot efficiently metabolize benzyl alcohol, leading to its accumulation and metabolic acidosis with respiratory failure in severe cases

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In some embodiments, the mucoadhesive agent is an alkyl-glycoside wherein the alkyl-glycoside is a disaccharide with at least one glucose