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Although the identity of the primary neural stem cell in the hippocampus and the lineage relationship between type 1 and type 2 cells is currently controversial (Tropepe, 2007), there is a consensus that the undifferentiated state and self-renewal of adult NPCs is controlled by the high-mobility-group DNA-binding protein Sox2 (Suh et al., 2007)

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In controlled in vitro models, researchers may evaluate receptor binding dynamics, signal transduction responses, and peptide stability, particularly in relation to its modified structure and extended activity profile under defined experimental conditions