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Post-translational modifications Ubiquitination regulates protein stability, localization, and function by covalently attaching ubiquitin to lysine residues on target proteins

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Recent studies have shown that insulin-mediated suppression of hepatic gluconeogenesis occurs indirectly through the ability of insulin to suppress adipocyte lipolysis and the flux into liver pyruvate carboxylase, the rate-limiting enzyme in gluconeogenesis (183, 200)