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Validation of the glutathione pathway in tissue regeneration PCR quantified the transcriptional activity of glutathione pathway enzymes—GCLC, GPXs, GSR, and GSTs—at various postoperative intervals (1 day, 1 week, 1, 2, and 6 months), with a significant peak at one month, indicating a robust enzymatic response during tissue remodeling (Fig
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Low Zn levels are associated with activation of Caspase-3 and downregulation of the ERK pathway, reduced Ki67-positive cells, increased TUNEL-labeled cells in the subgranular zone (SGZ), arrest of the cell cycle in the G0 G1 phase, promotion of apoptosis in neurons, and modification of cell signals that control the pro-survival and pro-apoptotic gene expression, such as NF-κΒ and p53 (189)