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269 Osteopontin plays significant role in determining the metastatic potential of various malignant tumors, 270 it can be inhibited by genistein in MDA-MB-435 and MDA-MB-231 cells, meanwhile, genistein can also decreased p-ERK1/2 and p-MEK1/2, and no alteration was observed in nucleus

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Shi et al [174, 222] examined synaptosomal fractions isolated from the frontal lobes of PD patients and find significantly increased levels of GSTpi protein