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Also, an essential point to remember in the cytoprotective effect of agents is capsaicin-sensitive afferent neurons[45,46], which regulate vascular function in many somatic and visceral tissues, including the regulation of local blood flow in the gastrointestinal tract

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The FDA has already approved some of the nasal drug delivery devices (mostly nasal spray) such as Zomig ® , Astelin ® , Narcan ® , Dymista ® , Advancia ® , Onzetra™, and Nasonex ® to treat different disorders

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