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The authors hypothesised that xCT inhibition might be further potentiated by limiting glutamate or glutamine availability, and show that xCT is a compelling therapeutic target for triple-negative tumours

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The Sugimoto 1995 study documented that copper ions inhibit type 1 5-alpha reductase by up to 90% in vitro, with 50% inhibition at 0.12 mcg copper/mL