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A growing body of work positions neuroinflammation as both spark and accelerant—microglia primed by gut-derived endotoxin, environmental toxins, or misfolded α-syn release a cocktail of IL-1β, TNF-α, and reactive oxygen species that undermines mitochondrial respiration and proteasomal flux [106,226,227]

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Combinatorial preconditioning of rat brain cultures with subprotective ethanol and resveratrol concentrations promotes synergistic neuroprotection