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[19] [20] They also claim that after approximately one year, or a maximum of 18 months, without successfully reunifying children with their birth families or finding them adoptive homes, children become permanent wards of the state, a status known as "permanent managing conservatorship" (PMC), and that after entering this permanent foster care status, many children have little hope for stable, permanent families and instead are shuffled between a variety of foster and institutional placements that are poorly supervised by the state
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FOXO4 plays a key role in regulating gene expression linked to cell cycle arrest, DNA repair processes, and resistance to oxidative stress