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Elevated serum triglycerides commonly associated with IR represent a valuable clinical marker of metabolic syndrome.[21] White adipose tissue is a major site of energy storage and it has been increasingly recognized as an important endocrine organ that secretes a number of biologically active “adipokines” (leptin, adiponectin, resistin), some of which (especially resistin and adiponectin) have been shown to directly or indirectly affect insulin sensitivity through modulation of insulin signaling and the molecules involved in glucose and lipid metabolism

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However, BIO increased significantly after 12 weeks of omega-3 FA but not omega-6 FA supplementation