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Compounds such as 3-indoxyl sulfate, which is known to promote the production of reactive oxygen species (ROS) and thus disrupt redox homeostasis 20 , were increased in IBM muscle (log2FC 2.16, FDR = 0.025), whereas metabolites that alleviate oxidative stress, such as indole-3 acrylate, were decreased (log2FC −4.44, FDR = 0.003)
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