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In primary cultures of alveolar epithelial cells from Nrf2 − / − mice, the higher levels of ROS result in activation of the ataxia telangiectasia mutated DNA damage-response pathway and impaired cell cycle progression, with the mutant cells exhibiting G 2 /M-phase arrest and fewer cells in S-phase [155]

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7 The number of flinches was counted for 1-min periods at 1 and 10 min (phase 1) and at 10-min intervals from 10 and 60 min (phase 2)