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First, Pb 2+ disrupts mitochondrial function, mainly due to Ca overload, including impairing key TCA cycle enzymes such as isocitrate dehydrogenase and α-ketoglutarate dehydrogenase, thereby reducing α-ketoglutarate availability for glutamate synthesis and energy production [109]

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In androgenetic hair loss, follicles miniaturize over time, so each new hair can come in thinner, shorter, and less visible